THIENO[2
MI-3
CAS: 1271738-59-0
Molecular Formula: C18H25N5S2
THIENO[2 - Names and Identifiers
THIENO[2 - Physico-chemical Properties
| Molecular Formula | C18H25N5S2 |
| Molar Mass | 375.55 |
| Density | 1.36±0.1 g/cm3(Predicted) |
| Boling Point | 527.9±60.0 °C(Predicted) |
| pKa | 9.59±0.40(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | In HEK293 cells, MI-3 approached the protein target and effectively inhibited the interaction by menin-MLL-AF9. MI-3 the MLL fusion protein-mediated leukemic transformation is effectively blocked by down-regulating the expression of a target gene required for the oncogenic activity of the MLL fusion protein. In human MLL leukemia cell lines carrying different MLL translocations, MI-3 effectively blocked cell differentiation and induced apoptosis. |
THIENO[2 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.663 ml | 13.314 ml | 26.628 ml |
| 5 mM | 0.533 ml | 2.663 ml | 5.326 ml |
| 10 mM | 0.266 ml | 1.331 ml | 2.663 ml |
| 5 mM | 0.053 ml | 0.266 ml | 0.533 ml |
Last Update：2024-01-02 23:10:35
THIENO[2 - Reference Information
| use | MI-3 (Menin-MLL inhibitor) can inhibit the carcinogenic activity of MLL fusion protein in leukemia. |
| biological activity | MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 648 nM. |
| In vitro study | In HEK293 cells, MI-3 approach protein targets and effectively inhibit menin-MLL-AF9 interactions. MI-3 can effectively block the transformation of leukemia mediated by MLL fusion protein by down-regulating the expression of target genes required for oncogenic activity of MLL fusion protein. In human MLL leukemia cell lines carrying different MLL translocation, MI-3 effectively block cell differentiation and induce cell apoptosis. |
| target | IC50: 648 nM (menin-MLL); Kd: 201 nM (menin-MLL) |
Last Update：2024-04-09 20:49:11
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CAS: 1271738-59-0
Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: MI-3 (Menin-MLL Inhibitor) Visit Supplier Webpage Request for quotationCAS: 1271738-59-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Menin-MLL inhibitor 3 Visit Supplier Webpage Request for quotationCAS: 1271738-59-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: MI-3 Visit Supplier Webpage Request for quotationCAS: 1271738-59-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Product Name: MI-3 Visit Supplier Webpage Request for quotation
CAS: 1271738-59-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1271738-59-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
THIENO[2
2,4-Imidazolidinedione, 5-[(4-chlorophenyl)methylene]-3-(4-methylphenyl)-
7-溴-5H-吡咯并[3,2-D]嘧啶-4-胺
Benzyl (3-(cyclopropanecarbonyl)phenyl)carbaMate
(TRIMETHYLSILYL)ACETIC ACID ETHYL ESTER
2-Cyclohexen-1-one, 3-hexyl-
(1H-咪唑-2-基)甲胺二盐酸盐
10H-Phenothiazin-2-amine, 10-[3-(4-methyl-1-piperazinyl)propyl]-
4'-(反式-4-丙基环己基)-2,3-二氟-4-乙氧基-1,1'-联苯
150671-05-9
2,4-Imidazolidinedione, 5-[(4-chlorophenyl)methylene]-3-(4-methylphenyl)-
7-溴-5H-吡咯并[3,2-D]嘧啶-4-胺
Benzyl (3-(cyclopropanecarbonyl)phenyl)carbaMate
(TRIMETHYLSILYL)ACETIC ACID ETHYL ESTER
2-Cyclohexen-1-one, 3-hexyl-
(1H-咪唑-2-基)甲胺二盐酸盐
10H-Phenothiazin-2-amine, 10-[3-(4-methyl-1-piperazinyl)propyl]-
4'-(反式-4-丙基环己基)-2,3-二氟-4-乙氧基-1,1'-联苯
150671-05-9